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Using two separate drugs to lose weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err on the side of caution and let the FDA do its job and demand some study be done so the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on the medications. Researchers discovered that participants taking this drug for any year, lost excess weight within 4 weeks and have kept the weight off during the entire 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of several active ingredient, that might make them more potent and safer. Combo-pilling is the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular will be the fact that by right now there aren't long term prescription slimming capsules that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise blood pressure and heartrate, and shouldn't be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and pulse rate and must 't be used in patients with uncontrolled high blood pressure, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients on the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. The most common negative effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.